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Samtidig brug af visse midler mod depression (Forex SSRI og SNRI) øger risiko for alvorlig forgiftning. Ved aftrapning kan det være svært at skelne, om en forværring af smerterne skyldes de smerter, du har pga. din sygdom/skade, eller om der er tale om abstinenser. Der kan forekomme forskelle mellem lægemiddelbeskrivelsen og indlægssedlen.